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dtu.dkMutation of Tyr245 or Tyr305 in SET7/9 (Figure 4b ) alters its specificity from an H3 K4 mono-methylase to a tri- and di-methylase, respectively sixteen , 21 , whereas an Phe281Tyr mutation in the lysine-binding pocket of DIM-5 (Figure 4c ) converts this protein to an H3 K9 mono- or di-methylase sixteen These mutations exemplify the F/Y swap (Figure 1 ) that establishes SET-area product specificities.

The Lysine 65 Residue in HIV-1 Reverse Transcriptase Operate and in Nucleoside Analog Drug Resistance. Weight-reduction plan is in the end about selecting higher lifestyle selections, not a fad